April 10th, 2019
A drug that is used to target specific types of gum bacteria could spell good news for Alzheimer’s sufferers.
Hundreds of patients could be given the drug COR388 after preliminary trials produced promising results. Researchers working on the drug analysed samples of brain tissue from patients who suffered from dementia when they died. They discovered that the samples contained higher than average levels of a bacterium known as Porphyromonas gingivalis (P.gingivalis) and toxins called gingipains. Tests conducted on mice revealed that gingipains can travel from the mouth to the brain, but that COR388 could prevent them from spreading.
Scientists suggest that gingipains facilitate the production of proteins known as beta amyloid and tatu, which are known to cause damage to brain cells and affect the ability to remember and retain memories. Researchers also found that P.gingivalis can be linked to rheumatoid arthritis and aspiration pneumonia.
Prof Jan Potempa, lead author of the study, explained that oral hygiene plays an instrumental role in our health throughout our lives, but stressed that those who have genetic risk factors that make them susceptible to dementia or rheumatoid arthritis should be particularly focused on maintaining healthy teeth and gums.
The drug COR388 has been developed by US company, Cortexyme Inc, which is renowned for producing medicines used to target neurological illnesses. A new trial, which involves a group of 570 patients who suffer from mild to moderate Alzheimer’s disease, will start in the near future with results expected in 2021.
Prof Potempa, from the University of Louisville’s Dental School, is working with the drug firm on other compounds that could also destroy P.gingivalis.
In the UK alone, around 850,000 people are affected by dementia, and the figure is expected to reach 2 million by 2050.
January 30th, 2019
Most of us know that brushing and flossing can help to keep our smiles sparkling, but did you know that caring for your gums could also help to reduce the risk of developing Alzheimer’s disease?
Previous studies have linked gum disease to an elevated risk of Alzheimer’s, but new research has shed light on the connection between oral health and the progressive neurological condition. Researchers have found traces of bacteria linked to advanced gum disease, known as Porphyromonas gingivalis, in the brains of people suffering from Alzheimer’s disease.
Tests conducted on mice revealed that it was possible for these strains of bacteria to travel around the body to the brain, and flagged toxic proteins secreted by this specific form of bacteria. This protein, known as gingipain, destroys neurons in the brain tissue. The presence of the bacteria also accelerated the production of amyloid beta, a form of plaque, which is connected to Alzheimer’s.
After discovering the bacteria, scientists analysed the impact of drugs used to inhibit the toxic proteins in mice, and found that they stopped neural degeneration.
The study authors suggested that the research highlighted the connection between specific strains of bacteria and gum disease and provided an insight into new treatment options. In light of the study findings, the team has developed a new drug, which they are hoping to test on humans as part of a clinical trial later in the year.
Prof Tara Spires-Jones, from the UK Dementia Research Institute, which is based at the University of Edinburgh, said that the drug trials involving mice provided positive news. She also added that it would be interesting to see the results of the human drug trials that are due to take place later this year.
July 19th, 2017
Dentists have urged parents to check food labels and nutritional information guidelines in a bid to crack down on rising rates of childhood decay.
Excessive sugar consumption is fuelling an epidemic of decay, which is resulting in thousands of young children ending up in hospital having teeth extracted under general anaesthetic The trouble is that while most of us know that sweets and chocolate bars are bad for the teeth, many ‘healthy’ snacks and drinks are flying under the radar.
If you take a packet of dried raisins, a shop-bought smoothie or a bottle of juice as an example, you may be shocked at the nutritional information you find if you look closely at the labels. It’s understandable to assume that you’re doing a good thing providing your children with dried fruit or a smoothie rather than a bag of sweets and a can of pop, but if you read the labels, you may actually find that the sugar content is very similar.
It can be very difficult to spot items that contain hidden sugar, especially those that are marketed as healthy alternatives, and dentists have urged parents to be vigilant. Foods like flavoured yoghurts can contain the same amount of sugar as a small chocolate bar, and even if you’re trying to be healthy, you may still find that your child’s daily sugar intake is higher than recommended. The advice from dentists is to read the labels, look for the green traffic light signals and try and make snacks and drinks like smoothies at home.
October 3rd, 2013
If there is a condition you need to tackle when it breaks out in your mouth with everything you have at your disposal in the city of London, its gum disease. This will not only violate all areas of your mouth, destroying your gums and teeth in the long run, it delivers more sinister blows throughout your body as well. Over a sustained period of time, the toxins from this disease will find their way into your heart and other vital organs and cause them to fail in the future. In the meantime, it can lead to halitosis and this is a condition that will seriously impair you both socially, and at work. Blood on the toothbrush after you have cleaned your teeth is the first sign that this disease is about and you may suffer from weeping gums as well which will not only taste bad, but will also smell bad; act now and you have a chance to beat it. Throw everything you can at this problem: your dentist will help fix the more obvious problems, but you also need to take a look at your lifestyle and personal oral hygiene in order to thwart the issue. You must turn things around quickly, so do your best if you want to remain healthy and have fresh breath; seek immediate advice and help.
September 12th, 2013
There are many things that can go horribly wrong in your mouth in the city of London: plaque is always a constant threat to your mouth and if you don’t deal with it, it can run riot in your mouth and become a very serious issue further down the line- it can all lead to gum disease. Getting through this however will take a lot of effort and if you don’t take care of your oral health, tame your bad habits (smoking and heavy drinking) and get your dentist on board, you will be getting yourself into serious problems and threatening the shelf-life of your teeth. Gum disease is a killer and it will ravish your mouth and if nothing is done about it, it will inevitably lead to tooth-loss- let alone what it will do to the rest of your body- like your heart. You have to look after yourself and if you ever feel you are free-falling into bad oral hygiene and your gums start to bleed after brushing, then get yourself along to your dentist and get some treatment and then shape-up at home as well with the way you look after your oral hygiene.
September 4th, 2013
Many modern dentists think that they have the lot in the city of London with all their modern machinery and new techniques…but not to dismiss all of this, these modern gadgets work amazingly well for the patients and give the best that the modern world of dentistry has to offer. But there is some strange parallel shift going on as well, for dentists have also got to grips with more natural, herbal remedies and these can also aid people with their problems. If for example you are having problems with gum disease, herbal products can help to take the sting and the heat out of your gums if you get into trouble: they can help improve the blood flow through the gums and settle a lot of problems down in the mouth. Finding out just what herbal products can do for you may take a lot of sitting down with your dentist, your hygienist and finding a top- notch person who knows all about everything herbal and can point you in the right direction, because using herbal products for your teeth is a precise art. Get it right though and you will have a very healthy mouth indeed.
August 26th, 2013
Your gums are a much prised procession in your mouth: they house your teeth and ensure that you have a stunning smile whenever you go dashing around central London. However, they are very delicate and are certainly not indestructible; they are also very vulnerable to infection and disease, so you need to put in a lot of effort to keep them healthy- as you do with your teeth. Food can easily get lodged in your teeth and up around your gums, so you should make flossing an important part of your oral cleaning each day. If you do start to have problems with your gums though, you need to pull out all the stops to settle them down again; massaging herbal products into them will promote blood flow and stimulate them. Bleeding gums need urgent attention as it could indicate disease has crept in; alter your oral hygiene, seek solace and advice from your dentist. Again, going herbal will help, as will rinsing your mouth out with salt water. But your gums don’t react well to smoking or a dodgy diet when they start to have problems, so you are going to have to think about altering your ways- that’s if you want to avoid the horror of gum disease and keep your teeth in your mouth for the rest of your life.
August 22nd, 2013
Some things in life can get nasty in you mouth in central London, but a particularly evil one is gum disease and you need to go ‘hell for leather’ in order to fight this off. Like most things that cause issues in your mouth, plaque is always the start of them; once this sticky film gets dug in, it will turn to tartar and once it starts to build up around the base of the teeth, it will begin to infect the gums and hence, you will be veering towards gum disease. In the early days, it is hard to spot, but the indication of early problems are when your gums bleed when you brush; your gums may also weep and leave a bad taste in your mouth. If you act quickly to fight it with better oral hygiene, diet and greater care for your mouth in general, you can overcome the threat. Get your dentist involved too, as well as a hygienist because they can advise you on where you are going wrong and help you to see the things that you have done to kick this disease off in the first place. But you should bear in mind the outcomes that gum disease can cause later down your life: your teeth will fall out and it will destroy the bone structure below, which will make repair work even harder to perform. Worse still, the toxins fed into the bloodstream by this disease will end up destroying your heart and other vital organs in your body.
July 16th, 2013
Plaque just never knows when to throw the towel in: always ready to strike, always ready get nasty and people in central London should always ensure that they maintain a high level of oral hygiene because when it is aloud to grow, it can then throw its big guns at you, like tooth decay and periodontal disease. Plaque is a horrible sticky substance that breeds from bacteria on the teeth and if not removed, it will quickly harden into tartar and strangle the life out of the gums, and then infect them. Once this happens, the gums will then start to pull away from the teeth, allowing the infection to move down into the bone structure below the tooth- you are now looking at tooth loss. All this can be prevented in the beginning and there is no excuse really because there are two things on your side- products and your dentist. More and more, the products on the shelves of shops are designed at dealing with plaque: there are plaque and tartar busting toothbrushes, toothpastes and mouthwashes; you can even get a dye that will show up the areas where plaque is lurking. Then you have your dentist who will spot tartar straight away and remove it. Getting rid of periodontal disease is not so easy though: it can take months to remove the infection after which, you may require bone and tissue grafts, so do yourself a favour, work harder at keeping your teeth clean.
June 25th, 2013
One of the many essential areas of the mouth that should be looked after in your mouth is your gums; if they are okay, then so will be the rest of your body and vice-versa, because if the gums become diseased, the heart and other organs can also become diseased and again, vice-versa: as it is with diabetes. If you have a well balanced body though, a good diet and a good immune system, it can help keep your gums healthy. Your lifestyle is also an important factor: gums hate smoking and other excesses so you should be careful with what you put into your mouth. Oral hygiene though is vitally important and a necessary part of cleaning is flossing; this can get up, in and around the gums to ensure that they are free from foodstuffs and bacteria. Gums also respond to being massaged, as this gets the blood flowing around them and the use of herbal products are excellent for this and can also help to diffuse any inflammation. Of course, don’t forget to visit a hygienist in the city of London from time to time, because your gums can get an MOT and be cleaned deep below for anything that you might have missed at home, plus advise you how to clean them and what to do if they show signs of problems flaring up.